Exploring Functional Candidate Genes for Genetic Association in German Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma
نویسندگان
چکیده
منابع مشابه
Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
PURPOSE Pseudoexfoliation (PEX) syndrome is a generalized elastic microfibrillopathy characterized by fibrillar deposits in intra- and extraocular tissues. Genetic and nongenetic factors are known to be involved in its etiopathogenesis. This study was focused on six functional candidate genes involved in PEX material deposition and the analysis of their potential association with PEX syndrome a...
متن کاملAssociation of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
PURPOSE Three common sequence variants in the lysyl oxidase-like 1 (LOXL1) gene were recently associated with both pseudoexfoliation (PEX) and pseudoexfoliation glaucoma (PEXG) in populations from Iceland and Sweden. In this study, the genetic association of these variants was investigated in patients with PEX or PEXG of German and Italian descent. METHODS The three LOXL1 single-nucleotide po...
متن کاملPseudoexfoliation Syndrome in Diabetic Patients
OBJECTIVE: Pseudoexfoliation syndrome (PEX) leads to some problems in the eye surgery specially cataract surgery. As the prevalence of eye problems is high in diabetic patients, we meant to assess the prevalence of PEX in diabetic patients. MATERIALS AND METHODS: In this cross-sectional study, 400 type 2 diabetic patients aged 50 or above who referred to Yazd Diabetes Research Center were sele...
متن کاملPrevalence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Upper Egypt
BACKGROUND Pseudoexfoliation (PXF) is a recognized risk factor for developing cataract, glaucoma and lens dislocation. PXF is also associated with increased risk of complications during cataract surgery due to poor mydriasis and zonular weakness. The aim of this study is to report the prevalence of pseudoexfoliation among Upper Egyptians attending the ophthalmology clinic of Assiut University H...
متن کاملEvaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma
Purpose. To compare the macular and peripapillary choroidal thickness in eyes with pseudoexfoliation (PEX) syndrome and PEX glaucoma with the normal eyes of healthy controls. Materials and Methods. In this prospective study, 30 eyes of 30 patients with PEX syndrome, 28 eyes of 28 patients with PEX glaucoma, and 30 eyes of 30 age-matched healthy subjects were enrolled. Choroidal thicknesses in t...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2009
ISSN: 1552-5783
DOI: 10.1167/iovs.08-2339